Compositions and treatments for Haemophilus influenzae
AssigneeThe Board of Regents of the University of Oklahoma
InventorsTerrence L. Stull, Daniel J. Morton, Thomas W. Seale, Paul W. Whitby
Life of this patent
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Abstract
Immunogenic peptides, fusion polypeptides, and carrier molecules which include the immunogenic peptides, and immunogenic compositions which include these immunogenic peptides, fusion polypeptides, and/or carrier molecules bearing the peptides, and which are able to elicit antibody production against Haemophilus influenzae (Hi), are disclosed. Also disclosed are methods of their use in causing an antibody response against one or more strains of Hi.
Claims18
A peptide composition, comprising a plurality of peptides comprising at least two different amino acid sequences, wherein each of the at least two different amino acid sequences is from an externally exposed loop of an outer membrane protein (OMP) selected from the group consisting of:
- SEQ ID NO:
- 97, SEQ ID NO:
- 101, SEQ ID NO:
- 589, SEQ ID NO:
- 462, SEQ ID NO:
- 590, SEQ ID NO:
- 308, SEQ ID NO:
- 123, SEQ ID NO:
- 139, SEQ ID NO:
- 245, SEQ ID NO:
- 460, SEQ ID NO:
- 328, SEQ ID NO:
- 329, SEQ ID NO:
- 153, SEQ ID NO:
- 321, SEQ ID NO:
- 325, SEQ ID NO:
- 145, SEQ ID NO:
- 350, SEQ ID NO:
- 268, SEQ ID NO:
- 341, and SEQ ID NO:
- 517,
- wherein each of the peptides induces an antibody response against a Nontypeable Haemophilus influenzae (NTHi), each of the peptides is linked together to form a fusion polypeptide, and a peptide at the amino-terminal end of the fusion polypeptide is duplicated at the carboxy terminal end of the fusion polypeptide.
A peptide composition, comprising a plurality of peptides comprising at least two different amino acid sequences,
- wherein each of the at least two different amino acid sequences is from an externally exposed loop of an outer membrane protein (OMP) and at least one of the amino acid sequences is SEQ ID NO:
- 328, and
- wherein each of the peptides induces an antibody response against a Nontypeable Haemophilus influenzae (NTHi), each of the peptides is linked together to form a fusion polypeptide, and a peptide at the amino-terminal end of the fusion polypeptide is duplicated at the carboxy terminal end of the fusion polypeptide.
A method of inducing an immunogenic response in a subject, comprising the step of:
- administering to the subject an amount of a peptide composition which is effective in stimulating an immunogenic response against Nontypeable Haemophilus influenza (NTHi) in the subject, wherein the peptide composition comprises at least two different amino acid sequences, wherein each the at least two different amino acid sequences is from an externally exposed loop of an outer membrane protein (OMP) selected from the group consisting of:
- SEQ ID NO:
- 97, SEQ ID NO:
- 101, SEQ ID NO:
- 589, SEQ ID NO:
- 462, SEQ ID NO:
- 590, SEQ ID NO:
- 308, SEQ ID NO:
- 123, SEQ ID NO:
- 139, SEQ ID NO:
- 245, SEQ ID NO:
- 460, SEQ ID NO:
- 328, SEQ ID NO:
- 329, SEQ ID NO:
- 153, SEQ ID NO:
- 321, SEQ ID NO:
- 325, SEQ ID NO:
- 145, SEQ ID NO:
- 350, SEQ ID NO:
- 268, SEQ ID NO:
- 341, and SEQ ID NO:
- 517, and
- wherein each of the at least two different amino acid sequences is able to induce an antibody response against NTHi, each of the peptides is linked together to form a fusion polypeptide, and a peptide at the amino-terminal end of the fusion polypeptide is duplicated at the carboxy terminal end of the fusion polypeptide.
Dependencies are inferred from the claim text.