Loading patent…
AssigneeAB Biosciences, Inc.
InventorsYen-Ming Hsu, Jeng-Shin Lee, Hsiu-Ching Chang
Estimating the term…
Compositions of recombinant intravenous immunoglobulin (rIVIG) proteins and methods for purification and use of rIVIG proteins. The compositions comprise oligomeric Fc molecules which bind to Fc receptors with high avidity. The rIVIG proteins are useful as immunomodulatory molecules for the treatment of immune disorders including autoimmune diseases, such as refractory immune thrombocytopenia, chronic inflammatory demyelinating polyneuropathy, multiple sclerosis, lupus, Graves Disease, Kawasaki disease, dermatomyositis, myasthenia gravis, Guillain-Barre syndrome, autoimmune hemolytic anemia, and other immune and inflammatory conditions. The rIVIG proteins can also be used as immunomodulators in patients to reduce the immune rejection of organ transplants, stem cell transplants and bone marrow transplantation. Additionally, the present invention provides rIVIG proteins of non-human origin, for use in veterinary immune disorders, such as canine rIVIG proteins for the treatment of dogs suffering from autoimmune hemolytic anemia, immune thrombocytopenia purpura, rheumatoid arthritis, or other canine immune disorder.
A recombinant intravenous immunoglobulin (rIVIG) polypeptide comprising (a) a CL domain, a CH1 domain, and a single chain Fc peptide comprising two CH2-CH3 Fc domains;
A method of reducing the immune rejection response of a patient who has received an organ transplant, said method comprising administering to said patient an effective amount of a composition comprising recombinant immunoglobulin (rIVIG) protein, wherein said rIVIG protein comprises a CL domain, a CH1 domain, a single chain Fc peptide comprising two CH2-CH3 Fc domains, and an oligomerization peptide domain, wherein the oligomerization peptide domain includes a collagen trimerization domain and the C-terminal end of the CL domain is linked to the N-terminal end of the CH1 domain by a short linker sequence.
A recombinant intravenous immunoglobulin (rIVIG) polypeptide comprising (a) a CL domain, a CH1 domain, and a single chain Fc peptide comprising two CH2-CH3 Fc domains;
A recombinant intravenous immunoglobulin (rIVIG) polypeptide comprising (a) a single chain Fc peptide comprising two CH2-CH3 Fc domains;
Dependencies are inferred from the claim text.