Flavonoid compositions and related methods
AssigneeInstituto de Investigaciones Cientificas y Servicios de Alta Tecnologia
InventorsCatherina C. Caballero-George, Andres Rivera Mondragon
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Abstract
Flavonoids that are isolated from plant material of the genus Cecropia can be used to perturb G-protein coupled receptors in a mammalian cell. In some instances, one or more flavonoids may interact with one or more of the G-protein coupled receptors to transiently increase the concentration of cytosolic calcium. Administration of the isolated flavonoids can be used to treat hypertension, to protect the integrity of blood vessels and related conditions.
Claims13
A method for producing a formulation for administration to a mammalian subject, the method comprising:
- mixing plant material with an alcohol, wherein the plant material is from one or more plants belonging to the Cecropia genus;
- extracting a portion of the plant material into the alcohol;
- isolating the extracted portion of plant material from a remainder of the plant material;
- removing at least a portion of the isolated extracted portion of the plant material to obtain a first composition, wherein the first composition comprises two or more flavonoids, the two or more flavonoids in the first composition being selected from the group consisting of isovitexin-2″-O-rhamnoside, isovitexin-2″-O-glucoside, isovitexin-2″-O-xyloside, isovitexin-O-xyloside, isoorientin-2″-O-xyloside, and mixtures thereof;
- and
- combining the first composition with a second composition to form the formulation for administration to the mammalian subject.
Dependencies are inferred from the claim text.