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US 11,304,957 B2Granted
Substituted quinazolines for inhibiting kinase activity
AssigneeNeupharma, Inc.
InventorsXiangping Qian, Yong-Liang Zhu
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Abstract
Chemical entities that are kinase inhibitors, pharmaceutical compositions and methods of treatment of cancer are described.
Claims6
A process for preparing a compound having the structure of Formula Ib″:
- comprising
- (i) contacting a compound having the structure of Formula F:
- with hydrogen in the presence of a palladium catalyst under conditions that provide a compound having the structure of Formula G:
- and
- (ii) contacting the compound having the structure of Formula G with a compound having the structure of Formula H:
- in the presence of an acid under conditions that provide a compound having the structure of Formula Ib″,
- wherein
- X1 is N or C—R2;
- each R1, R2, R4, and R5 is independently H or halo;
- R3 is optionally substituted heterocycloalkyl;
- and
- each R6, R12, R13, and R14 is independently H.
9 more elements
Dependencies are inferred from the claim text.