US 11,304,956 B2 · Use of 7-bromo-5-(O-chlorophenyl)-3-propoxy-1,2-dihydro-3H-1,4-benzodiazepin-2-one for inhibition of neuropathic pain and seizures of different etiology

Use of 7-bromo-5-(O-chlorophenyl)-3-propoxy-1,2-dihydro-3H-1,4-benzodiazepin-2-one for inhibition of neuropathic pain and seizures of different etiology

AssigneesAnatoly Semenovich Reder, Dmytro Volodymyrovich Pozigun

InventorsAnatoly Semenovich Reder, Sergey Andreevich Adronati, Mykola Yakovich Golovenko, Viktor Ivanovich Pavlovskiy, Tatiyana Anatolyevna Kabanova, Olena Igorivna Khalimova, Vitaly Borysovich Larionov, Natalia Ivanivna Voloshchuk

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Abstract

The invention relates to medical chemistry, in particular to the use of 7-bromo-5-(o-chlorophenyl)-3-propoxy-1,2-di-hydro-3H-1,4-benzodiazepin-2-one as a drug which inhibits neuropathic pain without the formation of defects in the gastric mucosa (ulcerogenic effect), and possesses an anticonvulsant property.

Claims4

Dependent claims

A method for treating neuropathic pain in a subject in need thereof, the method comprising administering to the subject a therapeutically effective amount of the compound of formula (I):

Dependencies are inferred from the claim text.

Facts

Application

16/338,902Filed 26 Oct 2017

Priority

UA A 2016 100833 Oct 2016

Published

US 2021/0169895 A110 Jun 2021

Granted

19 Apr 2022

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Classification11 codes

A61K 31/5513
Having two nitrogen atoms, e.g. dilazep: 1,4-Benzodiazepines, e.g. diazepam or clozapine
A61K 9/00
Medicinal preparations characterised by special physical form
A61K 9/0053
Galenical forms characterised by the site of application: mouth and digestive tract, i.e. intraoral and peroral administration
A61P 23/00
Anaesthetics