Dosing regimens associated with extended release paliperidone injectable formulations

A method for administering paliperidone palmitate to a patient in need thereof who has been administered a first dose of a first paliperidone palmitate extended-release injectable suspension (first suspension), the method comprising:

• administering in a deltoid muscle of the patient a re-initiation loading dose of a second paliperidone palmitate extended-release injectable suspension (second suspension) at a time that is more than six months and three weeks after administration of said first dose of the first suspension but less than eight months after administration of said first dose of the first suspension;
• and
• administering in a deltoid or gluteal muscle of the patient a maintenance dose of the first suspension at a time that is one month ±7 days after administering the re-initiation loading dose of the second suspension;
• wherein there is no intervening dose of paliperidone palmitate between the first dose of the first suspension and the re-initiation loading dose of the second suspension, and no intervening dose of paliperidone palmitate between the re-initiation loading dose of the second suspension and the maintenance dose of the first suspension;
• wherein the first suspension is a six-month extended release injectable suspension (PP6M), and the second suspension is a one-month extended release injectable suspension (PP1M).