2-hetarylpyrimidine-4-carboxamides as aryl hydrocarbon receptor antagonists

A compound of formula (I):

• wherein
• X is CH;
• Y is CR3;
• Z is CH;
• R1 is C2-C6-hydroxyalkyl, wherein said C2-C6-hydroxyalkyl groups are optionally substituted once with R7 and optionally one to three times with fluoro, or C4-C6-cycloalkyl substituted once with hydroxy and optionally one to two times with fluoro, or (C4-C6-cycloalkyl substituted once with hydroxy)-methyl, or 4-hydroxyoxolan-3-yl, 4-hydroxythiolan-3-yl or 4-hydroxy-1,1-dioxo-1lambda6-thiolan-3-yl;
• R2 is chloro, difluoromethyl, trifluoromethyl, or trifluoromethoxy;
• R3 is hydrogen;
• R4 is a group selected from the group consisting of
• wherein * indicates the point of attachment of said group with the rest of the molecule;
• R6a is hydrogen or methoxy;
• R6b is hydrogen, methyl, methoxy, or cyano;
• R6c is hydrogen, chloro, methyl, or cyano;
• R6d is hydrogen or methyl;
• R6e is hydrogen, methyl, isobutyl, or cyclopropyl;
• R6f is hydrogen or methyl;
• R6ff is hydrogen or methyl;
• R6g is hydrogen or methyl;
• R6h is hydrogen or methyl;
• R6i is hydrogen or methyl;
• R6k is hydrogen, chloro, or cyano;
• R6m is hydrogen or methyl;
• R7 is cyano, C3-C4-cycloalkyl, or pyridinyl;
• or
• a polymorph, an enantiomer, a diastereomer, a racemate, a tautomer, an N-oxide, a hydrate, or a solvate, a physiologically acceptable salt, or a solvate of a physiologically acceptable salt thereof.