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AssigneeThe Brigham and Women's Hospital, Inc.
InventorsJosephine Kahn, Siddhartha Jaiswal, Benjamin Ebert
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The present invention features methods for increasing sensitivity and/or reversing resistance to chemotherapy, methods for treating or preventing a cancer in a subject, methods for treating clonal hematopoiesis of indeterminate potential in a subject, and methods of identifying resistance or sensitivity to chemotherapy in a subject. In some embodiments, the methods contain the step of administering an agent that inhibits the expression or activity of a Protein phosphatase 1D (PPM1D) polypeptide or polynucleotide. The present invention also features compositions for increasing sensitivity and/or reversing resistance to chemotherapy.
A method of increasing sensitivity or reversing resistance of a blood or hematologic cancer cell to a chemotherapeutic agent or inhibiting proliferation of a blood or hematologic cancer cell, the method comprising contacting the blood or hematologic cancer cell which is or has become resistant to a chemotherapeutic agent with an effective amount of a Protein phosphatase 1D (PPM1D) inhibitor, thereby increasing sensitivity or reversing resistance of the blood or hematologic cancer cell to the chemotherapeutic agent, or inhibiting proliferation.
Dependencies are inferred from the claim text.