Sulfasalazine salts, production processes and uses
AssigneeMedac Gesellschaft Fuer Klinische Spezialpraeparate Mbh
InventorsMarguerite Mensonides-Harsema, Sebastian Bialleck
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AssigneeMedac Gesellschaft Fuer Klinische Spezialpraeparate Mbh
InventorsMarguerite Mensonides-Harsema, Sebastian Bialleck
Estimating the term…
Disclosed are a process for preparing new crystal salt forms of sulfasalazine, in particular crystal Form A of the D(−)-N-methylglucamine (meglumine) salt of sulfasalazine (see FIG. 1), crystal form A of the piperazine salt of sulfasalazine (see FIG. 2) and crystal Form B of the diethylamine salt of sulfasalazine (see FIG. 4), and a pharmaceutical composition containing one or more of the inventive crystal salt forms in particular in the treatment of a disease or condition in which modulation of inflammatory cells is beneficial, a disease or condition concerning bones or joints and/or the gastro-intestinal tract.
A crystal meglumine salt of Form A of 2-hydroxy-5-[2-[4-[(2-pyridinylamino)sulfonyl]phenyl]diazenyl]-benzoic acid (sulfasalazine) wherein the crystal is characterized by peaks in the powder x-ray diffraction at values (±0.2) of two theta of 6.35, 13.93, 15.48, 15.86, 20.99, 22.41, 23.60 and 28.07, and wherein the crystals contain 0 to less than 5 wt.-% solvate and/or water based on the total weight of the crystal meglumine salt of Form A of sulfasalazine.
Dependencies are inferred from the claim text.