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US 11,304,928 B2Granted
Tablet comprising 1-(3-(2-(1-benzothiophen-5-yl)ethoxy)propyl)azetidin-3-ol or salt thereof
AssigneeFUJIFILM Toyama Chemical Co., Ltd.
InventorsAtsushi Kano, Hiroyuki Inaba, Tai Oura
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Abstract
A tablet which comprises (1) 1-(3-(2-(1-benzothiophen-5- yl)ethoxy)propyl)azetidin-3-ol or a salt thereof and (2) ethyl cellulose, said tablet having excellent elution properties and good moldability, remaining stable during prolonged storage, and exhibiting high impact resistance.
Claims7
A tablet having improved impact strength comprising:
- (1) 1-(3-(2-(1-benzothiophen-5-yl)ethoxy)propyl)azetidin-3-ol or a salt thereof;
- (2) 2-5% based on the mass of the tablets ethyl cellulose
- (3) 0.5 to 3% based on the mass of the tablets of microcrystalline cellulose;
- (4) mannitol;
- and
- (5) from 0.1 to 10% based on the tablet mass of a disintegrant selected from the group consisting of croscarmellose sodium, crospovidone and mixtures thereof;
- and
- the tablet's impact strength is greater than that of a tablet of the same composition except not comprising ethyl cellulose when measured in the falling impact test.
5 more elements
Dependencies are inferred from the claim text.