Pharmaceutical compositions comprising nitroxyl donors
AssigneeCardioxyl Pharmaceuticals, Inc.
InventorsVincent Jacob Kalish, John Reardon, Frederick Arthur Brookfield, Stephen Martin Courtney, Lisa Marie Frost, John P. Toscano
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Abstract
The present disclosure provides nitroxyl donating pharmaceutical compositions comprising N-substituted hydroxylamine derivatives. The compositions are highly efficacious in treating cardiovascular diseases (e.g., heart failure), have a suitable toxicological profile, and are sufficiently stable for intravenous or oral administration.
Claims22
A method of treating heart failure, comprising intravenously administering to a human patient a nitroxyl donor composition comprising a compound of the formula (1):
- wherein said composition is administered at a pH of from about 5 to about 6.5 and at a dose of about 1 μg/kg/min to about 30 μg/kg/min.
A method of treating acute decompensated heart failure, comprising intravenously administering to a human patient a nitroxyl donor composition comprising a compound of the formula (1):
- wherein said composition is administered at a pH of from about 5 to about 6.5 and at a dose of about 1 μg/kg/min to about 30 μg/kg/min.
Dependencies are inferred from the claim text.