Methods and compositions for the treatment of Shiga Toxicosis
AssigneeBoard of Regents, The University of Texas System
InventorsSomshuvra Mukhopadhyay, Andrey S. Selyunin, Stanton F. McHardy
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Abstract
Methods for treating Shiga toxicosis, caused by infection with Shiga toxin bacteria, are provided. The methods include administering to a subject in need thereof an effective amount of one or more active agents selected from tamoxifen, 4-hydroxytamoxifen, endoxifen, toremifene, raloxifene, bazedoxifene, and pharmaceutically acceptable salts thereof. In some embodiments, the methods further include the administration of an antibiotic or a manganese compound to the subject. Pharmaceutical compositions for the treatment of Shiga toxicosis are also described.
Claims12
A method for treating Shiga toxicosis, the method comprising administering to a subject in need thereof an effective amount of an active agent selected from the group consisting of tamoxifen, 4-hydroxytamoxifen, endoxifen, toremifene, raloxifene, bazedoxifene, and pharmaceutically acceptable salts thereof.
Dependencies are inferred from the claim text.