Transdermal therapeutic system on the basis of adhesive plasticizer-polymer matrices

A transdermal therapeutic system, comprising a backing layer impermeable to active substances and a polymer matrix layer on one side of the backing layer impermeable to active substances, wherein the polymer matrix comprises at least one pharmaceutically active substance, at least one inherently non-adhesive polymer, wherein the inherently non-adhesive polymer comprises a polyvinyl caprolactam/polyvinyl acetate/polyethylene glycol copolymer, shellac, a vinylpyrrolidone/vinyl acetate copolymer, hyroxypropyl cellulose, hydroxypropyl methyl cellulose and/or polyvinylpyrrolidone, and the amount of the at least one inherently non-adhesive polymer in the matrix layer is approximately 50 to 90 wt. %, and at least one plasticiser, wherein the at least one plasticizer comprises glycerol and/or polyethylene glycol, the amount of the at least one plasticizer in the matrix layer is approximately 5 to 50 wt. % in relation to the total weight of the matrix layer, characterised in that the polymer matrix is free of inherently adhesive polymers.