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US 11,304,910 B2Granted
Soft gelatin capsules with pH-independent release
AssigneeAltergon S.A.
InventorsSimone Carucci, Maurizio Marchiorri, Marco Pontiggia, Tiziano Fossati
Life of this patent
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Abstract
Disclosed are soft gelatin capsules comprising a gelatin shell, a plasticiser, water, and optionally a calcium salt and a filling containing a dispersed or solubilised medicament comprising gelatin with gelling power, hydrolysed gelatin, glycerol, water, pectin and gellan gum. The formulations according to the invention allow gradual release of the active ingredient, regardless of pH.
Claims9
A soft gelatin capsule, wherein the capsule comprises
- a shell containing gelatin, a plasticizer, water and a calcium salt and
- a filling,
- wherein the filling contains a medicament dispersed or solubilised in a hydrophilic filling comprising from 1 to 5% of gelatin having a Bloom value ranging from 60 to 150 in percentages, said gelatin having gelling power, from 10 to 30% of hydrolyzed gelatin, from 10 to 30% of 85% glycerol, from 20 to 60% water, from 10 to 30% of pectin, up to 5% of gellan gum and from 0.1 to 10% of alcohol, the percentages being expressed by weight, on the total filling weight, wherein said soft gelatin capsule allows, in vitro, releasing of said medicament in a sustained pH-independent manner, said releasing beginning at the release time of said medicament and continuing for up to 360 minutes.
Dependencies are inferred from the claim text.