Tamper resistant dosage forms
AssigneesPurdue Pharma L.P., Purdue Pharmaceuticals L.P.
InventorsWilliam H. McKenna, Richard O. Mannion, Edward P. O'Donnell, Haiyong H. Huang
Life of this patent
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Abstract
The present invention relates to pharmaceutical dosage forms, for example to a tamper resistant dosage form including an opioid analgesic, and processes of manufacture, uses, and methods of treatment thereof.
Claims30
A method of treating pain comprising administering to a patient in need thereof a solid oral extended release pharmaceutical dosage form, comprising a shaped, convection heated, and cooled extended release matrix, said matrix comprising at least one polyethylene oxide (PEO) having, based on rheological measurements, an approximate molecular weight of at least 800,000, and at least one opioid analgesic, wherein (a) the shaped matrix is convection heated to an elevated temperature that is at least the softening temperature of said PEO for a time period of at least about 1 minute and thereafter cooled;
- and (b) a plurality of convection heated particles of PEO adhere to or fuse with each other within the matrix.
A method of treating pain comprising administering to a patient in need thereof a solid oral extended release tablet, comprising a shaped, convection heated, and cooled extended release matrix, said matrix comprising at least one polyethylene oxide (PEO) having, based on rheological measurements, an approximate molecular weight of at least 800,000, and at least one opioid analgesic, wherein (a) the shaped matrix is convection heated to an elevated temperature of at least 55° C. for a time period of at least about 15 minutes and thereafter cooled at a temperature below 50° C.;
- and (b) a plurality of convection heated particles of PEO adhere to or fuse with each other within the matrix.
Dependencies are inferred from the claim text.