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AssigneeAnovent Pharmaceutical (U.S.), LLC
InventorsCai Gu Huang, Hailong Zhang, Abid Hussain
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The present invention is directed to a liposomal formulation having a lipid ingredient encapsulating fluticasone furoate, and a method for preparing the liposomal formulation. The liposome formulation comprises a lipid and a sterol. The method of preparing the liposomes comprises the steps of (1) mixing fluticasone furoate with lipid ingredients comprising a lipid and a sterol, (2) injecting the mixture into normal saline solution, and (3) ultrafiltering and concentrating the resulting solution. This preparation method can produce a liposome formulation having desirable properties and compositions, for example, the ratio of the lipid ingredient, the drug to lipid ratio, and the pH value, which is suitable for nebulization inhalation.
A formulation comprising a suspension of a plurality of liposomes in a solvent, wherein the liposomes comprise a lipid ingredient that encapsulates fluticasone furoate, wherein the lipid ingredient comprises DPPC and cholesterol in a DPPC:cholesterol molar ratio of about 0.8:1 to about 1.2:1, the weight ratio of fluticasone furoate to lipid ingredient is about 1:30, the concentration of fluticasone furoate is about 1 mg/100 mL, and the solvent is normal saline.
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