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US 11,304,899 B2Granted
Compositions of fluorocarbon nanoemulsion, and methods of preparation and use thereof
AssigneeNuvOx Pharma LLC
InventorsEvan C. Unger, Edmund R. Marinelli
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Abstract
The invention provides novel compositions of fluorocarbon nanoemulsions comprising one or more of fluorosurfactants and phospholipids, and methods of preparation and use thereof for enhanced oxygen delivery.
Claims4
A composition of a fluorocarbon nanoemulsion comprising:
- perfluorohexane;
- and
- one or more surfactants selected from perfluoro-n-hexyl-oligoethyleneoxy-alcohols,
- wherein the nanoemulsion is characterized by:
- perfluorohexane accounting for a weight percent in the nanoemulsion from about 1% to about 10%,
- the perfluoro-n-hexyl-oligoethyleneoxy-alcohol accounting for a weight percent in the nanoemulsion from about 0.10% to about 7.5%,
- a particle distribution wherein 99% of the particles are measured to have particle diameters of less than or equal to 400 nm, and
- the perfluoro-n-hexyl-oligoethyleneoxy-alcohol is selected from the group consisting of:
5 more elements
A composition of a fluorocarbon nanoemulsion comprising:
- perfluorohexane;
- and
- a perfluoro-n-hexyl-oligoethyleneoxy-alcohol as a surfactant,
- wherein the nanoemulsion is characterized by:
- perfluorohexane accounting for a weight percent in the nanoemulsion from about 1% to about 10%,
- the perfluoro-n-hexyl-oligoethyleneoxy-alcohol accounting for a weight percent in the nanoemulsion from about 0.10% to about 7.5%,
- a particle distribution wherein 99% of the particles are measured to have particle diameters of less than or equal to 400 nm, and
- the perfluoro-n-hexyl-oligoethyleneoxy-alcohol is selected from the group consisting of:
5 more elements
Dependencies are inferred from the claim text.