Method of treating carcinoma
AssigneeSun Pharma Advanced Research Company Ltd.
InventorsWen Wee Ma, Alex Adjei, Lynne Bui, Ronald Harning, Ajay Khopade, Subhas Bhowmick, Natarajan Arulsudar, Narendra Lakkad
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Abstract
A method of treating patients suffering from carcinoma of intrahepatic or extra hepatic bile duct or gall bladder which is locally advanced or metastatic, by intravenously administering to the patient, paclitaxel in the form of a nanodispersion. The nanodispersion comprises particles with a mean particle size less than 300 nm and is free of polyoxyethylated castor oil and free of a protein.
Claims13
A method of treating a patient suffering from carcinoma of intrahepatic or extra hepatic bile duct or gall bladder which is metastatic, said method comprising intravenously administering to the patient, paclitaxel in the form of a nanodispersion,
- wherein said nanodispersion comprises
- (a) particles comprising (i) paclitaxel, (ii) a water soluble polymer, and (iii) a surfactant comprising a mixture of a fatty acid or a salt thereof and a sterol or a salt thereof, the particles having a mean particle size less than 300 nm, and
- (b) a water miscible solvent, wherein the nanodispersion is free of polyoxyethylated castor oil and is free of any protein, and
- wherein the paclitaxel is administered once in a 21 day cycle at a dose of 295 mg/m2.
A method of treating a patient suffering from metastatic carcinoma of the intrahepatic or extra hepatic bile duct or gall bladder who has failed to respond to one or more lines of treatment with one or more anti-cancer agents selected from mitomycin, 5-fluorouracil, cisplatin, oxaliplatin, leucovorin, capecitabine, bevacizumab, etoposide, gemcitabine, divotinib, cetuximab, regorafenib, carboplatin, lupron, casodex, bleomycin, pemetrexed, everolimus, sunitinib, crizotinib and doxorubicin, the method comprising intravenously administering to the patient paclitaxel at a dose of 295 mg/m2 in the form of a nanodispersion once in a 21 day cycle, wherein the nanodispersion comprises
- (a) particles comprising (i) paclitaxel, (ii) a water soluble polymer, and (iii) a surfactant comprising a mixture of a fatty acid or a salt thereof and a sterol or a salt thereof, the particles having a mean particle size less than 300 nm, and
- (b) a water miscible solvent.
A method of treating a patient suffering from adenocarcinoma of intrahepatic or extra hepatic bile duct or gall bladder which is (a) unresectable and (b) locally advanced or metastatic, said method comprising intravenously administering to the patient, paclitaxel in the form of a nanodispersion,
- wherein the paclitaxel is administered once in a 21 day cycle at a dose of 295 mg/m2,
- wherein said nanodispersion comprises
- (a) particles comprising (i) paclitaxel, (ii) a water soluble polymer, and (iii) a surfactant comprising a mixture of a fatty acid or a salt thereof and a sterol or a salt thereof, the particles having a mean particle size less than 300 nm, and
- (b) a water miscible solvent, wherein the nanodispersion is free of polyoxyethylated castor oil and is free of any protein.
Dependencies are inferred from the claim text.