Method of fabricating or modifying an implant

A method comprising:

• registering a plurality of intraoperative locations of a surgically resected anatomical region of a patient;
• generating, based on the registered plurality of intraoperative locations, a two-dimensional representation of the registered plurality of intraoperative locations;
• determining, based on the two-dimensional representation, a two-dimensional shape of an anatomical feature excised from the surgically resected anatomical region;
• determining, based on the two-dimensional shape of the anatomical feature and a three-dimensional model of a portion of the patient that contains the surgically resected anatomical region, a three-dimensional shape of the anatomical feature;
• and
• fabricating or modifying an implant based on the three-dimensional shape of the anatomical feature,
• wherein at least one of the plurality of intraoperative locations comprises a burr hole drilled during excision of the surgically resected anatomical region of the patient,
• wherein at least one of the plurality of intraoperative locations comprises a point along which a cut was made between adjacent burr holes during excision of the surgically resected anatomical region of the patient, and
• wherein determining the two-dimensional shape of the anatomical feature or determining the three-dimensional shape of the anatomical feature comprises defining edges of the two-dimensional shape or edges of the three-dimensional shape, respectively, based on the cut between adjacent burr holes.