Prosthetic valve with inflatable cuff configured to fill a volume between atrial and ventricular tissue anchors

A prosthetic valve for implantation within a native mitral valve, the prosthetic valve comprising:

• an annular valve body;
• a plurality of atrial anchoring arms configured to extend radially outward from the valve body;
• a plurality of ventricular anchoring legs configured to extend radially outward from the valve body;
• and
• a blood-inflatable cuff at least partially situated between the arms and legs, wherein the cuff is configured to substantially fill a volume between the arms and the legs when the cuff is fully inflated with blood,
• wherein a terminal portion of the at least one arm is situated within the cuff;
• and
• wherein at least one arm is configured to extend radially outward beyond the terminal end of at least one leg.