Methods and devices for tissue grasping and assessment

A fixation device for fixation of leaflets of a heart valve, comprising:

• a first distal element and a second distal element;
• a first proximal element moveable relative to the first distal element between a first position and a second position to grasp a first leaflet in a first target area defined by the first proximal element and the first distal element;
• a second proximal element moveable relative to the second distal element between a first position and a second position to grasp a second leaflet in a second target area defined by the second proximal element and the second distal element;
• a first indicator coupled with the first distal element to indicate a presence of the first leaflet in the first target area, the first indicator comprising one or more wire loops, wherein the first indicator extends into the first target area and is configured to at least one of change shape or change orientation by the presence of the first leaflet grasped within the first target area;
• and
• a second indicator coupled with the second distal element to indicate a presence of the second leaflet in the second target area, the second indicator comprising one or more wire loops, wherein the second indicator extends into the second target area and is configured to at least one of change shape or change orientation by the presence of the second leaflet grasped within the second target area.