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US 11,304,682 B2Granted
Non-invasive estimation of the mechanical properties of the heart
AssigneeUniversity of South Carolina
InventorsWilliam M. Torres, Francis G. Spinale, Tarek M. Shazly
Life of this patent
Estimating the term…
Abstract
Methods and systems for utilizing myocardial strain imaging in an inverse framework to identify mechanical properties of the heart and to determine structural and functional milestones for the development and progression to heart failure.
Claims8
A method for analyzing passive left ventricular myocardial stiffness comprising:
- measuring regional left ventricular geometry;
- measuring myocardial strain;
- estimating a ventricular pressure within an inverse finite-element network;
- computing regional left ventricular myocardial mechanical properties;
- and
- generating a spatiotemporal map;
- wherein an objective function in the form of:
- Π
-
-
-
- (
- A
- ′
- -
- A
- A
- +
- ∑
- i
- =
- 1
- 6
-
- (
- ɛ
- i
- ′
- -
- ɛ
- i
- ɛ
- i
- )
- +
- t
- ′
- _
- -
- t
- _
- t
- _
- )
- ×
- 100
-
- %
- .
- is developed as a function of, at least, actual end-diastolic area (A), regional strain (εi) relative to a reference mesh, and mean wall thickness (t) determined from an end-diastolic mesh.
47 more elements
Dependencies are inferred from the claim text.