Non-invasive blood glucose sensor

A non-invasive blood glucose meter comprising:

• a sensor body configured to mate with a tissue surface;
• a green light source;
• a blue light source;
• a red light source;
• an infrared light source;
• a photodetector disposed on the sensor body at a suitable position for capturing light emanating from the tissue surface after emission from the one or more light sources;
• and
• a controller programmed to:
• receive one or more signals from the photodetector;
• and
• calculate blood glucose value as function of at least the signals received from the photodetector after emission by at least one of the light sources;
• wherein the controller is further programmed to calculate the blood glucose value based on a function of at least one of the terms
• R
• +
• B
• +
• G
• B
• ,
• IR
• +
• B
• +
• G
• B
• ,
• and
• ⁢
• ⁢
• R
• +
• IR
• +
• B
• +
• G
• B
• ,
• wherein:
• B is a measure of amplitude of detected blue light;
• G is a measure of amplitude of detected green light;
• R is a measure of amplitude of detected red light;
• and
• IR is a measure of amplitude of detected infrared light.

A method of non-invasively determining a blood glucose level, the method comprising:

• receiving one or more absorption measurements of two or more wavelengths, wherein at least one of the two or more wavelengths includes one or more wavelengths selected from the group consisting of:
• blue light and green light;
• and
• calculating a blood glucose value based on a function of at least one of the terms selected from the group consisting of
• R
• +
• B
• B
• ,
• IR
• +
• B
• B
• ,
• R
• +
• IR
• +
• B
• B
• ,
• R
• +
• G
• G
• ,
• IR
• +
• G
• G
• ,
• R
• +
• IR
• +
• G
• G
• ,
• ⁢
• R
• +
• B
• +
• G
• B
• ,
• IR
• +
• B
• +
• G
• B
• ,
• R
• +
• IR
• +
• B
• +
• G
• B
• ,
• R
• +
• B
• +
• G
• G
• ,
• ⁢
• IR
• +
• B
• +
• G
• G
• ,
• and
• ⁢
• ⁢
• R
• +
• IR
• +
• B
• +
• G
• G
• wherein:
• B is a measure of amplitude of the blue light;
• G is a measure of amplitude of the green light;
• R is a measure of amplitude of red light in one or more absorption measurements;
• and
• IR is a measure of amplitude of infrared light in one or more absorption measurements.

A non-invasive blood glucose sensor comprising:

• a sensor body configured to mate with a tissue surface;
• a plurality of light sources configured to emit light to the tissue surface, the plurality of light sources comprising:
• a first blue light source disposed on the sensor body;
• a second blue light source disposed on the sensor body;
• a first green light source disposed on the sensor body;
• a second green light source disposed on the sensor body;
• a first red light source disposed on the sensor body;
• a second red light source disposed on the sensor body;
• an first infrared light source disposed on the sensor body;
• and
• a second infrared light source disposed on the sensor body;
• a photodetector disposed on the sensor body at a position for capturing light emanating from the tissue surface after emission from the plurality of light sources;
• and
• a controller programmed to:
• receive one or more signals from the photodetector;
• and
• calculate blood glucose value as function of at least the one or more signals received from the photodetector after emission by the plurality of light sources,
• wherein the controller is further programmed to calculate the blood glucose value based on a function of at least one of:
• a measure of detected amplitude of the first blue light;
• a measure of detected amplitude of the second blue light;
• a measure of detected amplitude of the first green light;
• a measure of detected amplitude of the second green light;
• a measure of detected amplitude of the first red light;
• a measure of detected amplitude of the second red light;
• a measure of detected amplitude of the first infrared light;
• and
• a measure of detected amplitude of the second infrared light;
• wherein the controller is further programmed to calculate the blood glucose value using an expression of μeν(Glucose Factor), wherein μ and ν are calibration constants.