Compositions and methods for identifying secretory antibody-bound microbes
AssigneeYale University
InventorsRichard Flavell, Noah Palm, Marcel de Zoete
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Abstract
The invention relates to the identification of secretory antibody-bound bacteria in the microbiota in a subject that influence the development and progression of inflammatory diseases and disorders. Thus, the invention relates to compositions and methods for detecting and identifying the constituents of a subject's microbiota, methods of modifying the constituents of the microbiota, and methods for treating inflammatory diseases and disorders in a subject in need thereof.
Claims10
A method of treating an inflammatory disease or disorder associated with a secretory antibody-bound bacteria in the microbiota of a subject in need thereof, the method comprising administering to the subject at least one therapy selected from the group consisting of at least one vaccine and at least one passive immunotherapy, wherein the at least one therapy induces an immune response directed against the secretory antibody-bound bacteria, wherein the secretory antibody-bound bacteria is Clostridium perfringens.
Dependencies are inferred from the claim text.