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US 11,299,740 B2Granted
Artificial chemical entity comprising a DNA oligonucleotide aptamer that selectively binds MUC1 antigen
OwnerOfer Nussbaum, Boaz Musafiainventors
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Abstract
Disclosed are artificial chemical entities, pharmaceutical compositions comprising such chemical entities and methods using the chemical entities. In some embodiments, the artificial chemical entity comprises a biomarker-bonding portion that selectively binds to a specified biomarker and an immune-response trigger that under in vivo conditions leads to positioning of an antibody Fc region in proximity of the biomarker to which the biomarker-bonding portion is bound.
Claims10
An artificial chemical entity, comprising:
- a. a biomarker-bonding portion comprising a DNA oligonucleotide aptamer that selectively binds to Muc1 antigen;
- and
- b. an immune-response trigger comprising IgG or an Fc region of IgG;
- wherein under in vivo conditions binding of the biomarker-bonding portion to Muc1 antigen on a cell positions the IgG Fc region in proximity of said Muc1 antigen.
1 more element
Dependencies are inferred from the claim text.