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US 11,299,733 B2Granted
Process of delivering small RNAs to sperm
AssigneeUniversity of Massachusetts
InventorsOliver Rando, Upasna Sharma, Colin Conine
Life of this patent
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AssigneeUniversity of Massachusetts
InventorsOliver Rando, Upasna Sharma, Colin Conine
Estimating the term…
Methods and compositions directed to altering a population of sRNAs in a sperm using vesicles isolated from an epididymosome are provided. Methods and compositions directed to altering a population of sRNAs in an oocyte using vesicles isolated from an epididymosome are also provided. Methods for altering an sRNA population in a sperm or an oocyte can be used to prevent, or reduce the severity of, a disease, disorder, or condition that would otherwise be inherited by progeny. For example, certain epigenetic inherited conditions due to paternal effects, such as certain metabolic and stress disorders and conditions, can be ameliorated in progeny using sperm or oocytes having an altered sRNA population.
A method of altering the sRNA population in a sperm, comprising contacting the sperm with a vesicle comprising an epididymosome loaded with a molecular cargo comprising a synthetic sRNA to produce a sperm having an altered sRNA population, wherein the sperm having an altered sRNA population is capable of fertilizing an oocyte.
Dependencies are inferred from the claim text.