System and method for creating tissue

A system for automatically growing tissue comprising:

• a controller providing commands to the system;
• a first subsystem responding to the commands, the first subsystem producing dissociated cells associated with the tissue and growth medium associated with the dissociated cells, the first subsystem including:
• a second subsystem responding to the commands, the second subsystem creating disassociated cells based at least on incoming cells, viral vectors, and commercial protein, the second subsystem providing the disassociated cells to a fifth subsystem;
• a third subsystem responding to the commands, the third subsystem creating the growth medium based at least on indicators, support materials, carbomer, basal media, and protein;
• and
• a fourth subsystem responding to the commands, the fourth subsystem receiving the protein from the fifth subsystem and supplying the protein to the third subsystem;
• the fifth subsystem responding to the commands, the fifth subsystem creating the tissue based at least on the dissociated cells and the growth medium;
• a sixth subsystem responding to the commands, the sixth subsystem growing the created tissue into a pre-selected mature tissue;
• a seventh subsystem responding to the commands, the seventh subsystem maintaining the viability of the pre-selected mature tissue;
• and
• a eighth subsystem responding to the commands, the eighth subsystem enabling transport of the viable mature tissue to a patient.

A system for automatically growing tissue comprising:

• a controller providing commands to the system;
• a first subsystem responding to the commands, the first subsystem producing dissociated cells associated with the tissue and growth medium associated with the dissociated cells;
• a second subsystem responding to the commands, the second subsystem creating the tissue based at least on the dissociated cells and the growth medium;
• a third subsystem responding to the commands, the third subsystem growing the created tissue into a pre-selected mature tissue;
• a fourth subsystem responding to the commands, the fourth subsystem maintaining the viability of the pre-selected mature tissue;
• and
• a fifth subsystem responding to the commands, the fifth subsystem enabling transport of the viable mature tissue to a patient;
• a tissue enclosure housing the tissue, the tissue enclosure including:
• a core including a cavity, the core having at least one monitoring area and at least one opening into the cavity, one of the at least one openings receiving the tissue, the core accommodating at least one material ingress and at least one material egress;
• and
• at least one filter assembly operably coupled with the core;
• wherein the tissue is confined within the cavity by the at least one filter assembly,
• wherein the life of the tissue is maintained by the maintenance subsystem at least by fluid flowing through the cavity between the at least one material ingress and the at least one material egress, and
• wherein the tissue is monitored through the at least one monitoring area.

A system for automatically growing tissue comprising:

• a controller providing commands to the system;
• a first subsystem responding to the commands, the first subsystem producing dissociated cells associated with the tissue and growth medium associated with the dissociated cells;
• a second subsystem responding to the commands, the second subsystem creating the tissue based at least on the dissociated cells and the growth medium;
• a third subsystem responding to the commands, the third subsystem growing the created tissue into a pre-selected mature tissue;
• a fourth subsystem responding to the commands, the fourth subsystem maintaining the viability of the pre-selected mature tissue;
• and
• a fifth subsystem responding to the commands, the fifth subsystem enabling transport of the viable mature tissue to a patient;
• a tissue enclosure housing the tissue, the tissue enclosure including:
• an incoming chamber admitting a first material, the incoming chamber emitting the first material in response to a differential pressure within the tissue enclosure;
• a core including a cavity, the core having at least one monitoring area and at least one opening into the cavity, the core accommodating at least one material ingress and at least one material egress, the core containing the tissue, the growth medium, and metabolism products from the tissue;
• at least one first filtration zone operably positioned between the incoming chamber and the core, the filtration zone subjecting the first material to at least one filter having a first pore size based at least on the first material, the filtration zone emitting first filtered contents to the core based at least on the first material and the first pore size;
• at least one second filtration zone operably coupled with the core, the at least one second filtration zone subjecting the first filtered material, the growth medium, the tissue, and the metabolism products to at least one filter having a second pore size based at least on the first filtered material, the growth medium, the tissue, and the metabolism products, the filtration zone emitting second filtered contents based at least on the first filtered material, the growth medium, the tissue, the metabolism products, and the second pore size;
• and
• an effluent chamber admitting the second filtered contents, the effluent chamber managing the filtered contents,
• wherein the tissue enters the cavity through the at least one opening, and
• wherein the tissue is confined within the cavity by the at least one first filtration zone and the at least one second filtration zone, and
• wherein the life of the tissue is maintained by the first material entering the cavity through the at least one material ingress and by the metabolism products exiting the cavity through the at least one material egress, and
• wherein the tissue is monitored through the at least one monitoring area.

A system for automatically growing tissue comprising:

• a controller providing commands to the system;
• a first subsystem responding to the commands, the first subsystem producing dissociated cells associated with the tissue and growth medium associated with the dissociated cells the first subsystem including:
• an organ scaffold hosting the tissue, the organ scaffold including:
• a fluid cavity enabling receiving and emitting fluids into the interior of the organ scaffold, the fluid cavity including an inner surface and an outer surface, the inner surface providing a boundary for the received fluids;
• a compliant wrapper operably coupled with the outer surface, the compliant wrapper enabling inflation and deflation of the fluid cavity;
• at least one layer of fiber disposed upon the compliant wrapper, the at least one layer of fiber disposed in the shape of the tissue;
• and
• a plurality of cells disposed upon the at least one layer of fiber, the plurality of cells being associated with the biology of the tissue;
• a tube operably coupled with the organ scaffold, the tube providing a conduit between a fluid source and the organ scaffold;
• and
• a chamber housing the organ scaffold, the chamber including at least one inlet and at least one outlet, the at least one inlet receiving fluids, the fluids maintaining viability of the tissue, the at least one outlet evacuating wastes from metabolism of the tissue;
• a second subsystem responding to the commands, the second subsystem creating the tissue based at least on the dissociated cells and the growth medium;
• a third subsystem responding to the commands, the third subsystem growing the created tissue into a pre-selected mature tissue;
• a fourth subsystem responding to the commands, the fourth subsystem maintaining the viability of the pre-selected mature tissue;
• a fifth subsystem responding to the commands, the fifth subsystem enabling transport of the viable mature tissue to a patient.