Methods for treatment of motor neuron diseases

A method of reducing muscle atrophy of a subject with amyotrophic lateral sclerosis (ALS), the method comprising administering to a subject in need thereof an effective amount of an anti-CTGF antibody that has the same amino acid sequence as the antibody produced by the cell line identified by ATCC Accession No. PTA-6006, thereby reducing muscle atrophy of the subject with ALS.

A method of preserving muscle strength of a subject with amyotrophic lateral sclerosis (ALS), the method comprising administering to a subject in need thereof an effective amount of an anti-CTGF antibody that has the same amino acid sequence as the antibody produced by the cell line identified by ATCC Accession No. PTA-6006, thereby preserving muscle strength of the subject with ALS.

A method of reducing nerve demyelination of a subject with amyotrophic lateral sclerosis (ALS), the method comprising administering to a subject in need thereof an effective amount of an anti-CTGF antibody that has the same amino acid sequence as the antibody produced by the cell line identified by ATCC Accession No. PTA-6006, thereby reducing nerve demyelination of the subject with ALS.

A method of reducing disease progression of a subject with amyotrophic lateral sclerosis (ALS), the method comprising administering to a subject in need thereof an effective amount of an anti-CTGF antibody that has the same amino acid sequence as the antibody produced by the cell line identified by ATCC Accession No. PTA-6006, thereby reducing disease progression of the subject with ALS.

A method of reducing loss of movement of a subject with amyotrophic lateral sclerosis (ALS), the method comprising administering to a subject in need thereof an effective amount of an anti-CTGF antibody that has the same amino acid sequence as the antibody produced by the cell line identified by ATCC Accession No. PTA-6006, thereby reducing loss of movement of the subject with ALS.