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US 11,299,535 B2Granted
Human IgE antibodies binding to aspergillus allergens
AssigneeVanderbilt University
InventorScott A. Smith
Life of this patent
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Abstract
The present disclosure is directed to antibodies binding to Aspergillus allergens and methods for use thereof.
Claims13
A monoclonal antibody, wherein the antibody or antibody fragment is characterized by heavy and light chain CDR1, CDR2 and CDR3 sequences of SEQ ID NOS:
- 17, 18 and 19 and SEQ ID NOS:
- 29, 30 and 31, respectively.
A method of producing an IgG immune response to an Aspergillus allergen comprising:
- (a) identifying an IgE epitope in an allergen by mapping the binding of an IgE antibody binding site, wherein said antibody has clone-paired heavy and light chain CDR1, CDR2 and CDR3 sequences of SEQ ID NOS:
- 17, 18 and 19 and SEQ ID NOS:
- 29, 30 and 31, respectively;
- (b) modifying one or more residues in said IgE antibody binding site to reduce or eliminate IgE antibody binding to said binding site, thereby producing a hypoallergenic Aspergillus allergen;
- (c) immunizing a subject with said hypoallergenic Aspergillus allergen to produce and IgG response to said hypoallergenic Aspergillus allergen, while producing a reduced or no IgE response as compared to the allergen of step (a).
2 more elements
Dependencies are inferred from the claim text.