Fusion protein comprising a ligand binding domain of VEGF and PDGF
AssigneesAllgenesis Biotherapeutics Inc., AP Biosciences, Inc.
InventorsKevin Zen, Pei-Tzu Wu, Jeng-Horng Her, Huang-Tsu Chen, Jiun-Shyang Leou, Ching-Hsuan Hsu
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Abstract
Fusion proteins containing a PDGF binding portion, a VEGF binding portion, and an Fc antibody region are described. Also described are nucleic acids encoding the fusion proteins, compositions comprising the fusion proteins, and methods of using the fusion proteins for treating or preventing clinical conditions characterized by abnormal angiogenesis, such as vascular permeability, edema or inflammation.
Claims18
A fusion protein consisting of:
- a. a first peptide consisting of an Ig-like domain D2 of a VEGFR1 and an Ig-like domain D3 of a VEGFR2,
- b. an Fc region of an antibody consisting of a CH2 and a CH3 region of IgG1,
- c. a second peptide consisting of Ig-like domains D1 to D3 of a PDGFRβ, and
- d. a linker peptide;
- wherein the fusion protein is arranged from N-terminus to C-terminus in an order selected from (a)-(b)-(d)-(c) or (c)-(b)-(d)-(a);
- and
- wherein the fusion protein is capable of binding to a VEGF and a PDGF and inhibiting the activity of the VEGF and the activity of the PDGF.
A fusion protein consisting of an amino acid sequence selected from the group consisting of SEQ ID NO:
- 38, SEQ ID NO:
- 40, amino acids 20-766 of SEQ ID NO:
- 42, amino acids 21-769 of SEQ ID NO:
- 44 and amino acids 20-768 of SEQ ID NO:
- 50.
Dependencies are inferred from the claim text.