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US 11,299,525 B2Granted
Chimeric antigen receptor-modified immune effector cell carrying PD-L1 blocking agent
AssigneeCrage Medical Co., Limited
InventorsZonghai Li, Zeyan Pan, Zhimin Shi, Bo Song, Peng Wang
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Abstract
Provided is a chimeric antigen receptor-modified immune effector cell carrying a procedural death ligand 1 (PD-L1) blocking agent. Also provided is a method for secreting and expressing a PD-L1 blocking agent using the immune effector cell as a carrier to improve the anti-tumour effect of the chimeric antigen receptor-modified immune effector cell.
Claims11
An immune effector cell modified to express:
- (i) a chimeric antigen receptor (CAR);
- and
- (ii) a PD-L1 blocking agent that is chosen from:
- (a) a soluble PD-1;
- (b) a fusion peptide of soluble PD-1 and CH3 domain of hIgG4e1-Fc;
- or
- (c) a fusion peptide of soluble PD-1 and hIgG4e1-Fc,
- wherein the PD-L1 blocking agent is not a component of the CAR, and
- wherein the soluble PD-1 comprises a signal peptide and an extracellular region of PD-1 but does not comprise a transmembrane domain of PD-1.
6 more elements
Dependencies are inferred from the claim text.