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US 11,299,524 B2Granted
KIF13B-derived peptide and method of inhibiting angiogenesis
AssigneeThe Board of Trustees of the University of Illinois
InventorsKaori Yamada, Asrar Malik
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Abstract
A construct composed of a Kinesin-derived Angiogenesis Inhibitor peptide and one or more carrier moieties and/or stabilizing moieties is provided as are methods for inhibiting angiogenesis and treating a disease or condition characterized by excessive vascularity.
Claims13
A construct of no more than 65 amino acids comprising the amino acid sequence Thr-Pro-Xaa1-Asp-Glu-Arg-Xaa2-Xaa3-Leu-Ile-Xaa4-Arg-Val-Xaa5-Val-Xaa6 (SEQ ID NO:2) operably linked to
- (a) one or more carrier moieties,
- (b) one or more stabilizing moieties, or
- (c) a combination of (a) and (b),
- wherein Xaa1 is Val, Ala or Ser;
- Xaa2 is Leu or Val;
- Xaa3 is Phe or Tyr;
- Xaa4 is Leu or Val;
- Xaa5 is Thr or Ala;
- and Xaa6 is Gln or Arg.
6 more elements
Dependencies are inferred from the claim text.