Substituted tetrahydropyran dihydrothienopyrimidines and their use as phosphodiesterase inhibitors

A compound of general formula (I)

• wherein:
• R1 is (C1-C4)alkyl;
• and
• R2 is selected from the group consisting of (C1-C4)alkyl, (C3-C6)cycloalkyl, bridged (C3-C6)cycloalkyl, (4-8 membered) heterocycloalkyl, bridged (4-8 membered) heterocycloalkyl, and phenyl;
• wherein the (C1-C4)alkyl, (C3-C6)cycloalkyl, bridged (C3-C6)cycloalkyl, (4-8 membered) heterocycloalkyl, bridged (4-8 membered) heterocycloalkyl, or phenyl is optionally substituted with one or more substituents independently selected from R3;
• R3 is selected from the group consisting of halogen, —CN, —OH, (C1-C4)alkyl, halo(C1-C4)alkyl, hydroxy(C1-C4)alkyl, (C1-C6)alkoxy, and halo(C1-C4)alkyloxy;
• and
• S* is a chiral sulfur atom with (R) stereochemistry;
• or a pharmaceutically acceptable salt, enantiomer, mixture of enantiomers, diastereomer, mixture of diastereomers, hydrate or solvate thereof.