Ligands for alpha-7 nicotinic acetylcholine receptors and methods of treating neurological and inflammatory conditions
AssigneesNortheastern University, University of Florida Research Foundation, Inc.
InventorsGaneshsingh A. Thakur, Abhijit R. Kulkarni, Roger Lee Papke
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Abstract
Compounds are provided which bind to an allosteric site on the mammalian alpha-7 nicotinic acetylcholine receptor (alpha-7 nAChR) and act as positive allosteric modulators with or without allosteric agonist activity. The compounds are useful in diagnosing, preventing, or treating a variety of disorders involving cognition, learning, memory, neurodegeneration, drug addiction, inflammation, chronic pain, and neuropathic pain. The compounds also can be used to enhance memory and learning in normal individuals.
Claims10
A compound having one of the following formulas:
- wherein the compound binds to an alpha-7 nicotinic acetylcholine receptor.
Dependencies are inferred from the claim text.