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US 11,299,493 B2Granted
Heterocyclic compounds and uses thereof
AssigneeNuvation Bio Inc.
InventorsSarvajit Chakravarty, Son Minh Pham, Jayakanth Kankanala, Anil Kumar Agarwal, Brahmam Pujala, Sanjeev Soni, Satish K. Arya, Deepak Palve, Ashu Gupta, Varun Kumar
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Abstract
Heterocyclic compounds as Wee1 inhibitors are provided. The compounds may find use as therapeutic agents for the treatment of diseases and may find particular use in oncology.
Claims34
A compound of the Formula (Ia-9):
- or a pharmaceutically acceptable salt thereof, wherein:
- R2 is C1-C6 alkyl or C3-C6 cycloalkyl;
- Y is hydrogen or R4;
- n and p are independently 0, 1, 2, 3, or 4;
- each R3a is independently C1-C6 alkyl optionally substituted by oxo, —OH or halogen;
- each R4 is independently C1-C6 alkyl,
- or two R4, when bound to the same carbon or two different carbon atoms, are taken together with the carbon or carbons to which they are attached to form a C3-C6 cycloalkyl.
4 more elements
A compound of the Formula (Ia-7):
- or a pharmaceutically acceptable salt thereof, wherein:
- R2 is isopropyl or C3-C6 cycloalkyl;
- Y is hydrogen or R4;
- n and p are independently 0, 1, 2, 3, or 4;
- each R3a is independently C1-C6 alkyl optionally substituted by oxo, —OH or halogen;
- each R4 is independently C1-C6 alkyl,
- or two R4, when bound to the same carbon or two different carbon atoms, are taken together with the carbon or carbons to which they are attached to form a C3-C6 cycloalkyl.
4 more elements
Dependencies are inferred from the claim text.