Thiazole compounds as protein kinase inhibitors
AssigneesNational Health Research Institutes, Taivex Therapeutics Corporation
InventorsWeir-Torn Jiaang, Yu-Sheng Chao
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Abstract
Thiazole compounds of Formula (I) shown below and pharmaceutical compositions containing one of such compounds: wherein R1 and R2 are defined in the specification. Also disclosed are methods of inhibiting a tyrosine kinase and treating cancer associated with a tyrosine kinase with one of the thiazole compounds.
Claims20
A compound of formula (I) below or a pharmaceutically acceptable salt thereof:
- wherein,
- R1 is C1-6 alkyl;
- and
- R2 is heteroaryl.
A pharmaceutical composition, comprising:
- a pharmaceutically acceptable carrier;
- and
- a compound of formula (I) below or a pharmaceutically acceptable salt thereof:
- wherein,
- R1 is C1-6 alkyl;
- and
- R2 is heteroaryl.
A method of inhibiting a tyrosine kinase, comprising contacting the tyrosine kinase with an effective amount of a compound of formula (I) below or a pharmaceutically acceptable salt thereof:
- wherein,
- R1 is C1-6 alkyl;
- and
- R2 is heteroaryl.
A method of treating cancer associated with a tyrosine kinase, the method comprising administering to a subject in need thereof an effective amount of a compound of formula (I) below or a pharmaceutically acceptable salt thereof:
- wherein,
- R1 is C1-6 alkyl;
- and
- R2 is heteroaryl.
Dependencies are inferred from the claim text.