Compounds and compositions as modulators of TLR signaling

A compound of Formula (A):

• or a tautomer, or a pharmaceutically acceptable salt of any of the foregoing,
• wherein
• R1 is —OH;
• R2 is —C(O)H;
• R3 is C1-C6alkoxy or halogen;
• G1 and G2 are each CH;
• indicates that the ring is aromatic;
• Y1 is C or N;
• Y2 is CH, N, NH, S, or O;
• Y3 is C or N;
• Y4 is CH, N, NH, S, or O;
• Y5 is CR7, N, NH, S, or O;
• wherein no more than one of Y1, Y2, Y3, Y4, and Y5 is S or O and no more than four of Y1, Y2, Y3, Y4, and Y5 are N or NH;
• R7 is H or C1-C6alkyl;
• n is 0, 1, 2, or 3;
• R4 is
• indicates that the ring is saturated, partially unsaturated, or fully unsaturated;
• G3 is CH(X1—R6a), C(X1—R6a), N, N(X1—R6a), S, or O;
• G4 is CH(X2—R6b), C(X2—R6b), N, N(X2—R6b), S, or O;
• G5 is CH(X3—R6c), C(X3—R6c), N, N(X3—R6c), S, or O;
• G6 is CH(X4—R6d), C(X4—R6d), N, N(X4—R6d), S, or O;
• and
• G7 is N, C, or CH;
• X1, X2, X3, and X4 are each independently absent,
• m is 1-6;
• R6a, R6b, R6c, and R6d are each independently hydrogen, C1-C6alkyl, C1-C6alkoxy, halo, —OH, —NRpRq, aryl, heterocyclyl, heteroaryl, —C1-C6alkyl-heterocyclyl, —OC(O)-heterocyclyl, —C(O)Rh, —S(O)2NRw1Rw2, —S(O)2Ry, or —NRz1S(O)2Rz2, wherein the C1-C6alkyl and C1-C6alkoxy of R6a, R6b, R6c, and R6d are each independently unsubstituted or substituted with one or more groups selected from the group consisting of cycloalkyl and halogen;
• the aryl and heteroaryl of R6a, R6b, R6c, and R6d are each independently unsubstituted or substituted with one or more groups selected from the group consisting of C1-C6alkyl, C1-C6alkoxy, C3-C8cycloalkyl, —OH, and C1-C6alkyl-OH;
• and the heterocyclyl, —C1-C6alkyl-heterocyclyl, and —OC(O)-heterocyclyl of R6a, R6b, R6c, and R6d are each independently unsubstituted or substituted with one or more groups selected from the group consisting of C1-C6alkyl, C1-C6alkoxy, halo, —OH, C1-C6alkyl-OH, ═O, and ═S;
• each Rh is independently selected from the group consisting of H, C1-C6alkyl, C1-C6alkoxy, and C3-C8cycloalkyl, and —NRrRs;
• each Rp is independently H or C1-C6alkyl;
• each Rq is independently C2-C3alkyl, —C(O)Rt, —C(O)ORu, or —C(O)NRv;
• each Rr, Rs, Rw1, and Rz1 is independently selected from H and C1-C6alkyl;
• and
• each Rt, Ru, Rv, Rw2, Ry, and Rz2 is independently selected from H, C1-C6alkyl, unsubstituted or substituted C3-C8cycloalkyl, and unsubstituted or substituted heterocyclyl;
• or
• G5 is CH(X3—R6c) or C(X3—R6c), G6 is CH(X4—R6d) or C(X4—R6d), and R6c and R6d are taken together with the carbon atoms to which they are attached to form a 6-membered aryl, a 6-membered heterocyclyl, or a 6-membered heteroaryl ring;
• wherein the 6-membered aryl, 6-membered heterocyclyl, and 6-membered heteroaryl rings are each independently unsubstituted or substituted.