Benzazole compounds and methods for making and using the compounds

A method of treating a hematological malignancy in a subject, comprising administering to the subject an effective amount of a compound having a formula

• or a pharmaceutically acceptable salt thereof, wherein:
• X is O or S;
• Het-1 is heterocyclyl;
• R1 and R2 independently are H, aliphatic, heteroaliphatic, heterocyclyl, aryl, araliphatic, or together with the nitrogen to which they are attached, form a heterocyclic ring;
• R3, R4, R5, R6 and R9 independently are H, aliphatic, halo, heteroaliphatic, —O-aliphatic, heterocyclyl, aryl, araliphatic, —O-heterocyclyl, hydroxyl, nitro, cyano, carboxyl, carboxyl ester, acyl, amide, amino, sulfonyl, sulfonamide, sulfanyl, sulfinyl or haloalkyl;
• R7 is H, aliphatic, heteroaliphatic, heterocyclyl, aryl or araliphatic;
• each R8 independently is aliphatic, halo, heteroaliphatic, —O-aliphatic, heterocyclyl, aryl, araliphatic, —O-heterocyclyl, hydroxyl, nitro, cyano, carboxyl, carboxyl ester, acyl, amide, amino, sulfonyl, sulfonamide, sulfanyl, sulfinyl or haloalkyl;
• and
• m is from 0 to 3;
• wherein treating the hematological malignancy comprises slowing the development of the malignancy, stabilizing the malignancy, or causing regression of the malignancy or a symptom thereof.