Chemical compounds

A compound of Formula (I), or a pharmaceutically acceptable salt thereof,

• wherein
• R1 is selected from H, R1a and —CH2OC(O)R1a, wherein R1a is selected from an unsubstituted C1 to C4 alkyl group and phenyl;
• {circle around (A)} is a cyclic group selected from C6 to C10 aryl and 5- to 10-membered heteroaryl;
• each R2 is independently selected from:
• (i) halo or R8;
• (ii) C1-3 alkyl, O(C1-3 alkyl), S(C1-3 alkyl), SO(C1-3 alkyl) or SO2(C1-3 alkyl), any of which may optionally be substituted with 1, 2 or 3 halo substituents and/or one R′substituent;
• and
• (iii) NRaC(O)Rc, and NRaC(O)NRbRc, wherein each Ra and Rb is independently selected from hydrogen and unsubstituted C1-2 alkyl and each Rc is unsubstituted C1-2 alkyl;
• and
• each R8 is independently selected from CN, OH, —C(O)NRfRg, —NRfRg, —NR10C(NR11)R12, —C(NR10)NR11R12, and —NR10C(NR11)NR12R13;
• wherein each of Rf and Rg is independently H or unsubstituted C1-2 alkyl;
• m is 0, 1, 2 or 3
• R3 is selected from hydrogen and a C1 to C3 alkyl group which is unsubstituted or is substituted with 1, 2 or 3 substituents selected from halogen, —OR10, and —NR10R11;
• n is 0 or 1
• Z is a bond or is selected from —NR10C(O)—, —C(O)NR10—, —NR10C(O)NR11—, —NR10C(O)O—, —OC(O)NR10, —NR10C(O)S—, —SC(O)NR10, —NR10C(NR11)—, —C(NR10)NR11—, —NR10C(NR11)NR12—, —NR10C(N+R11R12)—, —C(N+R10R11)NR12—, —NR10C(N+R11R12)NR13—, —NR10C(NR11)O—, —OC(NR10)NR11, —NR10C(N+R11R12)O—, —OC(N+R10R11)NR12—, —NR10C(NR11)S—, —SC(NR10)NR11, —NR10C(N+R11R12)S—, —SC(N+R10R11)NR12—, —C(O)NR15—, —NR10C(O)NR15—, —OC(O)NR15, —SC(O)NR15, —C(NR10)NR15—, —NR10C(NR11)NR15—, —C(N+R10R11)NR15—, —NR10C(N+R11R12)NR15—, —OC(NR10)NR15, —OC(N+R10R11)NR15—, —SC(NR10)NR15, and —SC(N+R10R11)NR15—;
• L is a bond or is selected from C1-4 alkylene, C2-4 alkenylene, C2-4 alkynylene, C1-3 alkylene-(C3-6cycloalkylene)-C1-3 alkylene, C1-4 alkylene-(C3-6cycloalkylene) and (C3-6cycloalkylene)-C1-4 alkylene, wherein L is unsubstituted or is substituted with 1 or 2 substituents selected from halogen, —OR10, and —NR10R11;
• or L is —C(R10)═N—;
• X is a bond or, when L is other than a bond or —C(R10)═N—, X is a bond or is selected from —NR10—, —O—, —NR10C(NR11)—, and —C(NR10)—;
• p is 0 or 1;
• R4 is selected from H, —CN and C1 to C3 alkyl which is unsubstituted or is substituted with 1, 2 or 3 substituents selected from halogen, —OR10, —NR10R11, and —CN;
• R5 is selected from H, —CN and C1 to C3 alkyl which is unsubstituted or is substituted with 1, 2 or 3 substituents selected from halogen, —OR10, —NR10R11, and —CN;
• R6 is selected from H, —CN and C1 to C3 alkyl which is unsubstituted or is substituted with 1, 2 or 3 substituents selected from halogen, —OR10, —NR10R11, and —CN;
• R7 if present is selected from H, —CN and C1 to C3 alkyl which is unsubstituted or is substituted with 1, 2 or 3 substituents selected from halogen, —OR10, —NR10R11, and —CN;
• each R10, R11, R12, and R13 is independently H or methyl;
• each R15 is independently substituted C1 to C4 alkyl or unsubstituted C2 to C4 alkyl, wherein when R15 is a substituted C1 to C4 alkyl group, the alkyl group is substituted with 1, 2 or 3 substituents independently selected from halogen, CN, OR10 and —NR10R11.