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US 11,299,462 B2Granted
Crystal form of oxopicolinamide derivative and preparation method therefor
AssigneeJiangsu Hengrui Medicine Co., Ltd.
InventorsJunran Yang, Lin Wang, Qiyun Shao, Zhenxing Du, Likun Wang
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Abstract
Provided are a crystal form of an oxopicolinamide derivative and a preparation method therefor. In particular, provided are crystal forms A, B, C, D, E, and F of a compound as shown in formula (I) and a preparation method therefor. Crystal forms A, B, C, D, E, and F of the compound of formula (I) obtained in the present disclosure have good crystal stability and chemical stability, and can be better used in clinical treatment.
Claims19
A crystal form of a compound of formula (I):
- selected from the group consisting of:
- (1) crystal form A having an X-ray powder diffraction spectrum comprising characteristic peaks at diffraction 2θ angels of 5.9, 8.8, 9.6, 13.8, 15.7 and 16.8;
- (2) crystal form B having an X-ray powder diffraction spectrum comprising characteristic peaks at diffraction 2θ angels of 7.5, 12.4, 13.1, 16.8 and 19.9;
- (3) crystal form C having an X-ray powder diffraction spectrum comprising characteristic peaks at diffraction 2θ angels of 7.4, 9.2, 13.3, 15.6, 15.9, 19.2, 21.7, 24.1, 24.9 and 27.3;
- (4) crystal form D having an X-ray powder diffraction spectrum comprising characteristic peaks at diffraction 2θ angels of 5.3, 6.4, 8.7, 11.5, 15.9, 16.3, 20.0 and 24.7;
- (5) crystal form E having an X-ray powder diffraction spectrum comprising characteristic peaks at diffraction 2θ angels of 6.6, 7.0, 8.9, 11.9, 15.1, 15.4, 16.3, 19.1, 19.9, 20.9, 23.5, 23.8, 24.3, 25.4, 26.6, 28.9 and 30.1;
- and
- (6) crystal form F having an X-ray powder diffraction spectrum comprising characteristic peaks at diffraction 2θ angels of 6.5, 7.51, 9.9, 11.3, 13.6 and 16.5.
5 more elements
Dependencies are inferred from the claim text.