Fabrication of macroporous polymeric hydrogel microparticles
AssigneeTrustees of Tufts College
InventorsHyunmin Yi, Eunae Kang, Sukwon Jung, John H. Abel
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Abstract
A polymeric hydrogel microparticle that contains polyacrylamide and chitosan, the chitosan uniformly incorporated in a polyacrylamide matrix. The microparticle, having a coefficient variation of 0 to 2% and containing macropores with an average size of 1 to 60 nm, is capable of transporting biomolecules conjugated to it. Also disclosed are a method of fabricating such a microparticle in a micromold via photo-induced radical polymerization and a one-pot method of conjugating biomolecules to polymeric hydrogel microparticles.
Claims12
A polymeric hydrogel microparticle comprising polyacrylamide and chitosan, the chitosan uniformly incorporated in a polyacrylamide matrix, wherein the microparticle has a coefficient of variation of 0 to 2% and contains macropores having an average size of 1 to 60 nm, wherein the chitosan has an average molar mass of 4,500-200,000 Da and the chitosan contains primary amines each having a pKa value of 6.0-6.9.
Dependencies are inferred from the claim text.