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US 11,298,563 B2Granted
Bactericidal methods and compositions
AssigneePulsethera, Inc.
InventorsPu-Ting Dong, Jie Hui, Ji-Xin Cheng, Yifan Zhu
Life of this patent
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Abstract
Methods of the present invention comprise photoinactivation of catalase in combination with low-concentration peroxide solutions and/or ROS generating agents to provide antibacterial effects.
Claims20
A method of treating a tissue of a subject infected with a catalase-positive microbe, said method comprising the steps of:
- applying visible light to the tissue of the subject infected with the catalase-positive microbe at a wavelength of about 400 nm to about 430 nm, wherein the catalase is inactivated, and subsequently contacting the tissue with a composition comprising a diluted peroxide solution, thereby treating the tissue of the subject infected with the catalase-positive microbe.
A method of producing a synergistic antimicrobial effect in a tissue of a subject infected with a catalase-positive microbe, said method comprising the steps of:
- applying visible light to the tissue of the subject infected with the catalase-positive microbe at a wavelength of about 400 nm to about 460 nm, wherein the catalase is inactivated, and subsquently contacting the tissue with a composition comprising a diluted peroxide solution, thereby producing the synergistic antimicrobial effect in the tissue of the subject infected with the catalase-positive microbe.
A method of treating a tissue of a subject infected with a catalase-positive microbe, said method comprising the steps of:
- applying visible light to the tissue of the subject infected with the catalase-positive microbe at a wavelength of about 400 nm to about 430 nm, wherein the catalase is inactivated, and subsequently contacting the tissue with a composition comprising a reactive oxygen species generating agent, thereby treating the tissue of the subject infected with the catalase-positive microbe.
Dependencies are inferred from the claim text.