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US 11,298,561 B2Granted
Method of treating multi-drug resistance biofilm using targeted laser and antibiotics
AssigneeThe United States of America as represented by the Secretary of the Navy
InventorNancy Millenbaugh
Life of this patent
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Abstract
This application describes a method of using gold nanoparticle (GNP)-targeted pulsed laser technology to enhance antibiotic efficacy against multidrug resistant biofilms. The application also teaches a method for treating topic wound infection using GNP-targeted laser therapy combined with antibiotics treatments.
Claims23
A method for treating a wound infection, comprising:
- a) introducing a composition into a wound, said composition comprising nanoparticles having an electron density that can couple with a photon wave of electromagnetic radiation, wherein said nanoparticles are capable of binding to one or more target microorganisms associated with wound infection;
- b) irradiating said wound by said electromagnetic radiation;
- and
- c) administering one or more therapeutic effective dose of an antimicrobial agent to said subject.
1 more element
A method for eradicating a microbiological film from a surface, the method comprising:
- a) introducing a composition into a microbiological film, the composition comprising nanoparticles having an electron density that can couple with a photon wave of electromagnetic radiation wherein said nanoparticles are capable of binding to one or more target microorganisms associated with the microbiological film;
- b) irradiating said microbiological film by said electromagnetic radiation such as to generate mechanical force for locally disrupting said microbiological film;
- and
- c) administering to said microbiological film one or more antimicrobial agent.
1 more element
Dependencies are inferred from the claim text.