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US 11,298,546 B2Granted
Systems and methods for minimizing response variability of spinal cord stimulation
AssigneeDuke University
InventorsWarren Grill, John Gilbert
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Abstract
This present disclosure provides systems and methods relating to neuromodulation. In particular, the present disclosure provides systems and methods for identifying optimized temporal patterns of spinal cord simulation (SCS) for minimizing variability in patient responses to SCS. The systems and methods of neuromodulation disclosed herein facilitate the treatment of neuropathic pain associated with various disease states and clinical indications.
Claims29
A method of identifying an optimized spinal cord simulation (SCS) pattern for use in delivering electrical stimulation to a subject for pain reduction, the method comprising:
- generating a plurality of SCS patterns using an optimization algorithm based on predetermined performance criteria, wherein the predetermined performance criteria comprise variance of pain score reduction across different pain states;
- evaluating the plurality of SCS patterns for pain reduction using a computational model of a neuronal network;
- identifying at least one candidate SCS pattern having an optimized temporal pattern of stimulation capable of reducing pain;
- and
- delivering the at least one candidate SCS pattern to the subject using a neuromodulation device.
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Dependencies are inferred from the claim text.