Methods, devices and systems for pulmonary delivery of active agents

A method of delivering to a pulmonary tract of a subject suffering from at least one physiological symptom at least one pharmacologically active agent for treating the at least one physiological symptom, the method comprising:

• providing the subject with an inhaler device associated with a controller which is preset with a personalized therapeutic window in which the at least one symptom for which the pharmacologically active agent was prescribed remains sufficiently alleviated, and at least one adverse effect induced by the pharmacologically active agent on the subject remains below a threshold;
• wherein the at least one adverse effect is not associated with the at least one physiological symptom being treated;
• vaporizing, at the inhaler device, a first metered amount of at least one pharmacologically active agent;
• delivering the first metered amount to the subject from the inhaler device;
• wherein the controller is preprogrammed with at least one predetermined effect to be induced in the subject by the at least one pharmacologically active agent;
• the at least one predetermined effect including the alleviation of at least one symptom that the subject is suffering from;
• receiving at the controller monitoring data indicative of at least one effect induced in the subject by the first metered amount;
• accessing data stored in a database, the stored data being other than the predetermined effect and other than the monitoring data;
• and
• vaporizing and delivering from the inhaler device, within a treatment regimen including the delivering of the first metered amount, a second metered amount of at least one pharmacologically active agent, wherein a magnitude of the second metered amount is automatically controlled by the controller based at least partially on the monitoring data, the data stored in the database and on the at least one predetermined effect;
• wherein the controller is configured for selecting the magnitude of the second metered amount in order to maintain the subject within limits of the therapeutic window.