Microstructured haptotaxic implant
AssigneeBVW Holding AG
InventorsLukas Bluecher, Michael Milbocker
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Abstract
The invention relates to the field of tissue engineering and regenerative medicine, and particularly to a three-dimensional biomimetic tissue scaffold that exploits the use of three-dimensional print technology. Surface energy is controlled by precisely placing polymers with differing surface chemistry, and using surface texture and bulk composition to pattern absorbable and non-absorbable polymers for the purpose of promoting functional healing in a mammalian body.
Claims20
A three-dimensional matrix for tissue regeneration comprising at least three successive layers of at least two biocompatible polymers that are solid at temperature below 36° C., the layers arranged to form walls with open voids therebetween, the voids suitable for seeding or ingrowth of cells, the layers comprising a first polymer and a second polymer, the first or second polymer comprising polyester urethane, polyether urethane or a combination thereof, and wherein the first and second polymers are disposed in an alternating pattern along at least one axis of the matrix, wherein the first polymer is hydrophobic and/or lipophilic and the second polymer is hydrophilic;
- and
- wherein the matrix has a surface energy, the surface energy being varied on at least three spatial scales comprising 1) a macro scale ranging from 50 micron to 1 mm obtained by forming layers of polymers of different surface energy, 2) a meso scale ranging from 1 micron to 50 micron obtained by placing a surface pattern on the polymers, and 3) a fine-scale of less than 1 micron obtained by variation of molecular structure.
A three-dimensional matrix for tissue regeneration comprising:
- a substrate having at least three successive layers of at least two biocompatible polymers that are solid at temperature below 36° C., the layers arranged to form walls with open voids therebetween, the voids suitable for seeding or ingrowth of cells, the layers comprising a first polymer and a second polymer, comprising polyester urethane, polyether urethane or a combination thereof, and wherein the first and second polymers are disposed in an alternating pattern along at least one axis of the matrix, wherein the first polymer is hydrophobic and/or lipophilic and the second polymer is hydrophilic;
- an implantable layer wherein the substrate is disposed on the implantable layer;
- and
- wherein the matrix has a surface energy, the surface energy being varied on at least three spatial scales comprising 1) a macro scale ranging from 50 micron to 1 mm obtained by forming layers of polymers of different surface energy, 2) a meso scale ranging from 1 micron to 50 micron obtained by placing a surface pattern on the polymers, and 3) a fine-scale of less than 1 micron obtained by variation of molecular structure.
Dependencies are inferred from the claim text.