Method for labeling radioisotope radiolabeling compound and kit comprising the same for labeling radioisotope

A kit for labeling a radioisotope comprising:

• a diaminophenyl compound represented by Chemical Formula I and including a biomolecule, a fluorescent dye or a nanoparticle compound bound thereto;
• and
• a radioisotope-labeled aldehyde compound represented by Chemical Formula II,
• in Chemical Formula I,
• A is CH2 or O;
• a is 0 or an integer of 1 to 10;
• X is CH2 or —CONH—;
• Y is CH2 or
• and Z is the biomolecule, the fluorescent dye or the nanoparticle compound,
• in Chemical Formula II, b is 0 or an integer of 1 to 10;
• and L is CH2 or —CONH—;
• and
• Q is
• each of M, M′ and M″ in Q is a radioisotope.

A radioisotope-labeled biomolecule, a radioisotope-labeled fluorescent dye or a radioisotope-labeled nanoparticle compound, represented by Chemical Formula IV below:

• in Chemical Formula IV,
• A is CH2 or O;
• a is 0 or an integer of 1 to 10;
• X is CH2 or —CONH—;
• Z′ is a structure excluding a thiol group in a biomolecule, fluorescent dye or nanoparticle compound including the thiol group or substituted with the thiol group;
• b is 0 or an integer of 1 to 10;
• and L is CH2 or —CONH—;
• and
• Q is
• each of M, M′ and M″ in Q is a radioisotope.

A composition for medical diagnosis comprising:

• a radioisotope-labeled biomolecule, a radioisotope-labeled fluorescent dye or a radioisotope-labeled nanoparticle compound represented by Chemical Formula IV below, as an active ingredient:
• in Chemical Formula IV,
• A is CH2 or O;
• a is 0 or an integer of 1 to 10;
• X is CH2 or —CONH—;
• Z′ is a structure excluding a thiol group in a biomolecule, fluorescent dye or nanoparticle compound including the thiol group or substituted with the thiol group;
• b is 0 or an integer of 1 to 10;
• and L is CH2 or —CONH—;
• and
• Q is
• each of M, M′ and M″ in Q is a radioisotope.