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US 11,298,429 B2Granted
Adeno-associated virus vector delivery of microrna-29 to treat muscular dystrophy
AssigneeResearch Institute At Nationwide Children's Hospital
InventorsLouise Rodino-Klapac, Jerry R. Mendell, Kristin N. Heller
Life of this patent
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Abstract
The invention provides for recombinant AAV vectors comprising a polynucleotide sequence comprising the guide strand of miR-29c and methods of using the recombinant vectors to reduce or prevent fibrosis in subjects suffering from muscular dystrophy.
Claims20
A recombinant AAVrh74 vector comprising the nucleic sequences of SEQ ID NO:
- 3 or SEQ ID NO:
- 4.
Dependencies are inferred from the claim text.