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AssigneesConsejo Superior De Investigaciones Cientificas (Csic), Universidad Publica de Navarra
InventorsMaría Jesús Grilló Dolset, Beatriz San Román Aberasturi, Leyre Palacios Chaves, Sara Mena Bueno, Ana Zabalza Baranguá
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The present application provides a modified Brucella strain, its use as a medicament, and its use as a medicament for the treatment and/or prevention of brucellosis. The Brucella strain has been modified through an inactivation of the wzm gene. Further, the present application provides a pharmaceutical composition which comprises the modified Brucella strain, its use as a medicament, and its use as a medicament for the treatment and/or prevention of brucellosis. The present application also provides a kit which comprises the modified Brucella strain and a pharmaceutically acceptable carrier or diluent and its use for the treatment and/or prevention of brucellosis.
A method for prevention of brucellosis, comprising administering to a subject a modified Brucella melitensis Rev1 strain, wherein the wzm gene has been inactivated, wherein the method is for prevention of brucellosis in cattle, goats, sheep, pigs, dogs, or combinations thereof, and the brucellosis is caused by an infectious agent selected from the group consisting of B. melitensis, B. abortus and B. ovis.
Dependencies are inferred from the claim text.