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US 11,298,401 B2Granted
Compositions and uses of antimicrobial materials with tissue-compatible properties
AssigneeAmicrobe, Inc.
InventorsMichael P. Bevilacqua, Diego Benitez, Jarrod A. Hanson
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Abstract
Compositions comprising a mixture of an antimicrobial cationic polypeptide and a second pharmaceutically-acceptable polymer are disclosed, as well as methods and uses thereof for the treatment and prevention of infections that occur when our natural barriers of defense are broken.
Claims17
A method of treating a biofilm, comprising:
- selecting a site capable of supporting biofilm formation;
- applying to the site a composition comprising one or more synthetic polypeptide(s) having a length of at least 40 amino acid residues;
- wherein the one or more synthetic polypeptide(s) has a net cationic charge at neutral pH;
- wherein the one or more synthetic polypeptide(s) has at least one cationic segment with a plurality of positively charged amino acid residues and at least one hydrophobic segment with a plurality of hydrophobic amino acid residues;
- and
- wherein the synthetic cationic polypeptide(s) are configured to self-assemble into multimeric structures in an aqueous composition,
- wherein the one or more synthetic polypeptide(s) inhibits or kills microbes in biofilms.
4 more elements
Dependencies are inferred from the claim text.